Dwight Gayle suffered a recurrence of his hamstring problem in Newcastle United's 2-0 win over Aston Villa.
Gayle had been handed his first start in more than a month after recovering from a hamstring problem.
But the striker limped off in the 33rd minute after signalling to the bench.
United manager Rafa Benitez said: "It’s the same problem. He’ll miss some games but hopefully it’s not too bad."
Gayle was replaced by Aleksandar Mitrovic.
Newcastle went on to win thanks to a strike from Yoan Gouffran and an own goal from Henri Lansbury.