But what about the other contenders? Who do the bookies think will go and who do they think will be safe?
Here we take a look at the runners and riders using SkyBet’s Premier League relegation odds.
1. Sheffield United - 5/4
They might have picked up three points on Saturday but the bookies still make Chris Wilder & Co favourites for the drop. | Getty Images Photo: Shaun Botterill
2. Newcastle United - 5/4
Things are looking grim on Tyneside at present - and that's reflected in the odds. Two losses out of two, one goal and seemingly a million and one problems. | Getty Images Photo: Marc Atkins
3. Norwich City - 7/4
Daniel Farke's men were rampant against Newcastle on Saturday, scoring three which so easily could have been six or seven. Written off by many, they might just prove people wrong. | Getty Images Photo: Jordan Mansfield
4. Aston Villa - 2/1
Newly-promoted Villa are one of four teams who have lost their opening two Premier League fixtures. | Getty Images Photo: Alex Morton