A 2-0 victory against the Hammers during last season’s opener provided plenty of optimism for Magpies fans before it all descended into a relegation battle.
Steve Bruce’s side will be hoping the upcoming term fetches better times ahead and that they won’t have to worry about the prospect of dropping into the Championship.
But are the bookmakers backing United to retain their top-flight status once more?
Here are the latest relegation odds for every Premier League club via SkyBet:
1. Manchester City - 2000/1
Not a chance will the champions go down with Pep Guardiola’s side favourites to retain their Premier League crown. Photo: Michael Regan
2. Manchester United - 1000/1
Finished as runners-up to neighbours Man City last season - and they’ll need to get over the disappointment of losing the Europa League final, too. Photo: GARETH COPLEY
3. Liverpool - 1000/1
A season of struggle for Jurgen Klopp’s men but a strong finish ensured a third-place finish and Champions League football. Photo: PAUL ELLIS
4. Chelsea - 1000/1
Champions of Europe. Now, Thomas Tuchel’s side will target their first Premier League title since 2017. Photo: SUSANA VERA