Mr Johnson is expected to tell MPs upon their return from Parliament’s February recess that the vaccine programme, testing and new treatments can be relied upon to keep the public safe.
It comes after ministers said new variants of the virus are expected to follow a similar pattern to Omicron in being more mild than early Covid-19 mutations.
Speaking ahead of outlining his plan, the Prime Minister said: “Covid will not suddenly disappear, and we need to learn to live with this virus and continue to protect ourselves without restricting our freedoms.
“We’ve built up strong protections against this virus over the past two years through the vaccine rollouts, tests, new treatments, and the best scientific understanding of what this virus can do.
“Thanks to our successful vaccination programme and the sheer magnitude of people who have come forward to be jabbed, we are now in a position to set out our plan for living with Covid this week.”
By the end of the week, self-isolation regulations will be scrapped for those who test positive and their close contacts, officials said.
Local authorities will be required to manage outbreaks with pre-existing public health powers, as they would with other diseases.
Downing Street said pharmaceutical interventions will “continue to be our first line of defence”, with the vaccine programme remaining “open to anyone who has not yet come forward”.
With 85% of the UK’s population double-vaccinated, and 38 million booster jabs administered, No 10 said it had concluded “Government intervention in people’s lives can now finally end”.
However, No 10 appeared to keep the door open to state-funded infection sampling remaining in place, following reports that Covid studies could be withdrawn as part of the plan.
Officials said Monday’s “living with Covid” plan, as well as removing quarantine impositions, will maintain “resilience against future variants with ongoing surveillance capabilities”.
It comes after senior statistician Sir David Spiegelhalter argued that some form of the Office for National Statistics’ coronavirus study should remain in place.
The Cambridge University professor, who is a non-executive director for the ONS and chairman of the advisory board for the Covid Infection Survey, told BBC Radio 4’s Today programme the results had been vital for monitoring people’s behaviour.
“It has been absolutely so important as we have gone along,” he said on Saturday, February 19.
“It has been running since April 2020, and so, as I said, I do have a bias here but it is not just me – I think lots of people are saying how important it is, particularly the statistical community.”
Covid-19 restrictions were first brought into action in March 2020, with the first national lockdown in England announced on Monday, March 23.