Newcastle United take on Maurizio Sarri's side at St James's Park (4pm kick-off).
And Rafa Benitez, playing a five-man defence, has handed summer signings Federico Fernandez, Fabian Schar and Ki Sung-yueng their competitive debuts.
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There's also a first start for Salomon Rondon, who starts up front ahead of Joselu.
United tweeted that Shelvey (thigh) and Lascelles (ankle) were missing because of injuries.
Captain Lascelles is understood to have had a disagreement with Benitez over tactics ahead of the game.
Midfielder Sean Longstaff is among the substitutes after impressing in pre-season.
NEWCASTLE UNITED: Dubravka, Yedlin, Schar, Fernandez, Clark, Dummett; Ritchie, Ki, Diame, Murphy; Rondon. Subs: Darlow, Sterry, Longstaff, Atsu, Muto, Perez, Joselu.
CHELSEA: Kepa, Azpilicueta, Rudiger, Luiz, Alonso, Kante, Jorginho, Kovacic, Pedro, Hazard, Morata. Subs: Caballero, Barkley, Loftus-Cheek, Giroud, Zappacosta, Willian, Christensen.