The collison happened close to junction 69 of the road at Team Valley.
Drivers have been advised to avoid the area.
Northumbria Police tweeted: "Police are currently dealing with an RTC A1 Junction 69.
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"Northbound slip road for the A184.
"Only Lane 1 is in use at the moment.
"Lanes 2 & 3 blocked.
"Please avoid the area wherever possible. Thank you."