The annual event sees people of all ages gather as to raise awareness of the illness which can turn the lives of those living with the condition upside down.
Last year, the walk was moved to the Bents Park in South Shields after it outgrew it’s previous venues.
The walk organised by the Alzheimer’s Society is expected to attract 5,000 walkers on Saturday.
The event is the charity’s flagship fundraising event and will be officially started by BAFTA award-winning actor John Middleton who played vicar Ashley Thomas from Emmerdale. In the soap, his character was diagnosed with dementia.
A spokesman for the charity said: “The Memory Walk is Alzheimer’s Society’s flagship fundraising event of the year, when thousands walk in memory of – or to pay tribute to – loved ones affected by dementia.”
Those taking part in the walk will have the choice of a 2km route along Sea Road and the promenade or a longer route which will take people along the South Shields coastline.
Alzheimer’s Society research shows 850,000 people in the UK have a form of dementia, about 35,000 of them in the North East.
The walk on Saturday starts at 11am. Those taking part are asked to meet at Bents Park for 10am.
Registration to take part closes today.
For details and to register visit www.memorywalk.org.uk