The southbound carriageway was closed near the junction at the A195 following a 10-vehicle crash - and has now been cleared and reopened.
The collision is believed to have been caused by adverse weather as drivers battled difficult conditions across the region.
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A spokesman for Northumbria police said: "At about 6am this morning police received a report of a multi-vehicle collision on the A1 southbound carriageway near to the junction with the A195.
"It was believed that 10 vehicles had been involved in a collision which at this stage is believed to have been caused by adverse weather.
"Emergency services attended after a collision which required seven cars to be uplifted.
"Two people are believed to have suffered serious but non-life threatening injuries.
"Traffic had been diverted on to the A195 but the road has since been re-opened.
"A gritter has also attended due to ice on the road.
"There have been multiple collisions across the region this morning due to the weather and police would ask that drivers take care on the roads and drive to the conditions."
Motorists faced serious delays in the area and traffic is believed to have been backed up to the Metrocentre at Gateshead.
At about 6am today (April 4), police received a report of a multiple vehicle collision on the A1 just after Washington Services.
A diversion was put in place whilst services worked to clear the road but it has since reopened.