Paul Dummett will come up against Newcastle United team-mates Georginio Wijnaldum and Daryl Janmaat as Wales host Holland in Cardiff tonight.
The left-back will hope to stake a claim for a place in Wales' Euro 2016 squad, while Wijnaldum and Janmaat are part of a Dutch side undergoing an extreme makeover following their shock failure to qualify for next Summer's tournament in France.
Meanwhile, Moussa Sissoko's French side host World Champions Germany at the Stade de France, with the midfielder hoping to win his 33rd cap for the national side. Former United midfielder Hatem Ben Arfa is also in Didier Deschamps' squad after a recall.
Elsewhere, Aleksandar Mitrovic will hope to find his goalscoring touch as the striker's Serbia side travel to the Czech Republic, while Shane Ferguson – who is currently on loan at League One Millwall – is set to be in action for Northern Ireland as they host Latvia at Windsor Park.
Last night saw Chancel Mbemba's DR Congo scrape past Burundi 3-2 in their World Cup qualifier, thanks to two late goals, while Adam Armstrong captained England Under-19's to a 2-2 draw with the Netherlands. Goalkeeper, Freddie Woodman was an unused substitute.