Aleksandar Mitrovic has been handed his first start of the season away at Manchester United.
Papiss Cisse drops down to the bench, with Steve McClaren handing his summer signing the chance to impress up front.
Steven Taylor comes in for the suspended Daryl Janmaat, serving a one match ban after his red card at Swansea City.
While Ayoze Perez has been given a start, replacing the injured Moussa Sissoko out with a groin strain.
Siem de Jong returns to the bench after a shin injury.
Newcastle are lining up in their favoured 4-2-3-1 formation, with Mitrovic leading the line.
Louis Van Gaal has handed Bastian Schweinsteiger his first start of the season, with Michael Carrick named on the bench.
Man Utd (4-2-3-1): Romero, Darmian, Blind, Smalling, Shaw, Schneiderlin, Schweinsteiger, Januzaj, Mata, Memphis, Rooney (C).
Subs: Johnstone, Chicharito, Young, Carrick, Herrera, Valencia, McNair.
Newcastle (4-2-3-1): Krul, Mbemba, Taylor, Coloccini (C), Haidara, Colback, Anita, Wijnaldum, Obertan, Perez, Mitrovic.
Subs: Darlow, Williamson, de Jong, Aarons, Thauvin, Tiote, Cisse.