Mauricio Pochettino admits Harry Kane may be rested for Tottenham's Europa League match against Monaco tonight.
Mousa Dembele missed training on Wednesday after coming down with a stomach bug.
And key players like Kane could also sit out the clash ahead of Sunday's home game against Newcastle United given that Spurs are already through to the knock-out stages.
A draw against Monaco will ensure Mauricio Pochettino's side finish first in the group, which would also guarantee them a seeding going into the last 32.
Kane, however, has played in all of Tottenham's 21 fixtures so far this season, and endured a hectic summer after going to Australia on the club's post-season tour and then playing for England's under-21s.
"Is it a chance to rest him? Maybe yes," Pochettino said.
"He is in the squad for tomorrow, but it is true we need to assess him."
Pochettino has resisted the temptation to make wholesale changes in the Europa League so far, and suggested he will retain a number of core players again.
"There may be one or two more changes, but not much," Pochettino said.
"I think the squad we have is strong enough to compete in different competitions, but maybe if you compare (the team) to the game against Qarabag there will be some changes, but not too much."
Pochettino added: "Always it is tough, it was a tough decision when we played against Qarabag and now it's tough again.
"Always we share the information with the sports science and medical department. We make the best decision for every game.
"Tomorrow is a good opportunity to finish first and win the group - this is our objective."