Paul Dummett has made himself unavailable to play for Wales, according to Chris Coleman.
The defender, yet to play in a competitive international, has won two caps.
Dummett played in all but one of Newcastle's 46 Championship games this season.
The 25-year-old won praise from manager Rafa Benitez throughout the campaign, but he was not named in Wales' latest squad.
Coleman named seven uncapped players for training camp in Portugal ahead of next month's World Cup qualifier against Serbia.
said: "He doesn't want to play international football, which is a disappointment from our point of view.
"But he's made that decision, and we have to abide by that.
"We'll get on with the squad of players, the squad who want to play and represent Wales.
"There's nothing we can do with Paul, who's decided that international football is not the path he wants to go down."
Wales manager Coleman says he was informed of Dummett's decision by the Newcastle-born player's agent.
"Sometimes you have to be patient, especially because the team we have at the moment has been hugely successful," said Coleman.
"It's a shame, because he's a good player. I haven't spoken to Paul. His agent rang me up to give me the news.
"I was disappointed, but if he doesn't want to persevere with it then that's his choice.
"We've got to look after the players who want to play for us".
Wales, third in World Cup qualifying Group D, are four points behind leaders Serbia.
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