Christian Atsu is doubtful for Newcastle United's visit to Old Trafford.
The winger has had to withdraw from Ghana's squad for Sunday's World Cup qualifier against Egypt because of a thigh injury.
Atsu will now return to Tyneside to be assessed ahead of the November 18 fixture against Manchester United.
Ghana's FA tweeted: "Tests have revealed that winger Christian Atsu will not play for #Ghana in Sunday's World Cup qualifier against Egypt.
"Team doctor says the scans show @ChristianAtsu20 suffered a thigh muscle tear."