Sean Longstaff will make his full Premier League debut against Chelsea.
Newcastle United take on Maurizio Sarri's side at Stamford Bridge this evening (5.30pm kick-off).
And midfielder Longstaff, 21, has been handed a start in Rafa Benitez's midfield.
Benitez, United's manager, is without Mohamed Diame, Ki Sung-yueng and Jonjo Shelvey.
Defender Florian Lejeune, meanwhile, will also made his first league appearance of the season after recovering from a long-term knee injury.
Benitez has named four defenders on his bench along with Joselu and Jacob Murphy.
Newcastle could be in the relegation zone at kick-off time depending on results elsewhere.
NEWCASTLE UNITED: Dubravka; Yedlin, Lejeune, Lascelles, Clark, Ritchie; Atsu, Hayden, Longstaff, Perez; Rondon. Subs: Woodman, Sterry, Manquillo, Fernandez, Schar, Murphy, Joselu.
CHELSEA: Kepa; Azpilicueta, Rüdiger, David Luiz, Marcos Alonso; Jorginho, Kanté, Kovacic; Willian, Hazard, Pedro. Subs: Caballero, Christensen, Emerson, Ampadu, Barkley, Hudson-Odoi, Giroud.