Newcastle United travel to Burnley looking to secure an unlikely top 10 finish despite failing to win any of their opening 14 matches. Meanwhile, The Clarets will be looking to secure their Premier League status at Turf Moor with relegation still a possibility if they fail to equal or better Leeds United’s result.
Elsewhere, Manchester City and Liverpool head into the final day with both still able to secure the Premier League title. Man City lead by a point and have a plus six goal difference advantage as they prepare to host Aston Villa.
Liverpool, who face Wolverhampton Wanderers at home, simply need to win and hope City drop points against Steven Gerrard’s side.
The competition for the European places is also still alive with Arsenal needing to beat Everton and hope Tottenham Hotspur lose away to bottom side Norwich City in order to secure a place in next season’s Champions League.
Just below, Manchester United and West Ham will find out whether they will be playing Europa League or Europa Conference League football next season.
The Red Devils are away to Crystal Palace while West Ham are at Brighton. The Hammers need to win and hope Man United drop points at Selhurst Park in order to leapfrog them into sixth place.
At the bottom of the table, Leeds travel to Brentford looking to secure their Premier League safety while Chelsea host Watford and Leicester City are at home to Southampton.
Here, we take a look at how the supercomputer, courtesy of FiveThirtyEight, predicts the final round of Premier League fixtures will unfold.