The Magpies’ first Premier League game came on August 14, 1993 when they faced Tottenham Hotspur.
In their debut season, they remarkably finished in third position and ever since then, the Newcastle journey has stopped off at title-challengers, European football, mid-table mediocrity, flirting with relegation, eventual relegation a brief European journey before being back to flirting with relegation again.
It started with Kevin Keegan and in their 1000th game, they will be led out by Steve Bruce.
For 27 seasons, United have been on a Premier League roller-coaster, but what do the stats tell us about their journey?
Have they racked up more wins than defeats? How many goals have they scored?
Here, we have summarised everything you need to know about Newcastle’s last 999 games in the Premier League:
1. Wins: 369
Newcastle have won over one-third of their Premier League games. Their first came courtesy of a Malcolm Allen goal in a 1-0 win against Everton. Their biggest was the 8-0 win against Sheffield Wednesday in Sir Bobby Robson’s first game in charge. (Mandatory Credit: Clive Mason /Allsport) Photo: Clive Mason
2. Draws: 255
Last time-out against Southampton took Newcastle’s draw tally to 255. Possibly their most famous came against Arsenal and they remain the only ever Premier League team to overturn a four-goal deficit to grab a point. (Photo credit should read GRAHAM STUART/AFP via Getty Images) Photo: GRAHAM STUART
3. Defeats: 375
Predictably, Newcastle’s time in the Premier League started with a defeat to Tottenham Hotspur on August 14, 1993. Their heaviest defeats in the competition came in 6-0 defeats to Manchester United in 2008 and Liverpool in 2013. (Photo by Michael Steele/Getty Images) Photo: Michael Steele
4. Points: 1362
The highest points total Newcastle have reached in a single Premier League season came in 1995/96 where they recorded 78 points. Their lowest points-haul came in 2008/09 where they managed just 34 points from their 38 games. (Photo by Clive Brunskill/Allsport/Getty Images) Photo: Clive Brunskill