The Sunderland striker walked out ahead of his country’s 2018 World Cup qualifier against Lithuania holding the hand of the five-year-old cancer battler, from Blackhall Colliery.
Goalkeeper Joe Hart, who was named England captain for the match, kindly allowed the pair who have become close friends in recent months, to lead the team onto the pitch.
And Bradley proved to be a good luck omen for Jermain, who opened the scoring with a first-half strike and went on to be named Man of the Match.
A Jamie Vardy goal in the second-half saw England win the qualifier 2-0.
Scores of readers took to the Facebook to leave comments of support for Bradley, who has terminal neuroblastoma.
Lesley Ghazi wrote: “Wow, brought tears to my eyes, keep fighting Bradley.”
Yvette Boundy said: “That smile is magic.”
Linda Willis wrote: “Bradley you’re amazing hope you had a fab day at the football. You are Jermain are heroes.”
Tracey Thompson added: “Never stops smiling that boy, so brave.”
Linda Farrow wrote: “Bradley & Jermain have touched my heart.”
Julie Bee wrote: “Ah it’s just so fab a true partnership between them. Bradley you are a very brave young man.”
John Dannell added: “Just melts my heart.”
Valerie Metcalf said: “Nice touch from Joe Hart letting Defoe and Bradley lead out the team.
“Really have a good relationship!”
Pauline Johnson added: “The special bond these two have is just amazing.”
Louise Manning wrote: “Bradley a true super hero.”
And Debbie Lorraine wrote: “Over the moon for them both!”