The Welsh beauty is set to perform at Sunderland's Herrington Country Park in the spring as part of a programme of events run by The Northern Sessions.
Jenkins, who will also wow crowds at the Queen's 90th birthday celebration at the Royal Albert Hall this year, is the first act to be announced by the company as part of an exciting line-up for the city in 2016.
The Northern Sessions, a division of Sunderland Live, announced plans earlier this month to bring a number of top acts to the North East across the summer months.
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Securing the singer and songwriter, who was awarded an OBE in the New Year Honours 2014, as the first was a "massive coup", a spokesperson said.
“We think this will be a fantastic event which should attract people from around the region and beyond.”
The mezzo-soprano has sold more than four million copies of her 10 studio albums worldwide, and also appeared on TV shows Pop Star to Opera Star and Dancing With The Stars.
The singer will be accompanied by the National Symphony Orchestra, and conducted by Anthony Inglis.
Ticket holders are being encouraged to bring blankets, ground covers or folding chairs on the night if they wish to sit.