
Newcastle United take on Walter Zenga's side in a third-round tie (7.45pm kick-off) three days after losing to them in the Championship.
Wolves won 2-0 on Saturday thanks to an own goal from Chancel Mbemba and a strike from Helder Costa.
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United manager Benitez – whose side beat Cheltenham Town in the last round of the EFL Cup – has made a number of changes for the rematch.
As expected, striker Daryl Murphy and left-back Achraf Lazaar make their Newcastle debuts in the tie.
Karl Darlow starts in goal, while Grant Hanley and Ciaran Clark are partnered in central defence.
NEWCASTLE UNITED: Darlow; Yedlin, Hanley, Clark, Lazaar; Shelvey, Colback; Ritchie, Diame, Gouffran; Murphy. Subs: Woodman, Dummett, Lascelles, Hayden, Atsu, Perez, Mitrovic.
WOLVERHAMPTON WANDERERS: Lonergan; Silvio, Iorfa, Hause, Borthwick-Jackson; Coady, Teixeira, Saville; Mason, Gladon, Wallace. Subs: Ikeme, Batth, Doherty, John, Price, Oniangue, Bodvarsson