Natalie McIntyre was last seen around 10pm on Tuesday, February 11, at her home address on Mill Dam, South Shields.
A public appeal, which includes a picture of Natalie, has been launched in a bid to help trace her.
Police officers, who are searching for the 31-year-old, are growing increasingly concerned for her welfare.
They are asking anyone who sees her to get in touch with police by calling 101.
A spokesman for Northumbria Police said: “She is described as 5ft 3in, medium build with blonde bobbed hair.
“She is thought to be wearing black pump style shoes, khaki green cargo trouser and a black top with gold bands on the sleeves.
“Natalie, or anyone who has information for police, should contact the control room on 101 quoting log 768 12/02/20.”