Newcastle United's injury list has gained five more players over the past week following matches against Fulham and Chelsea.
Alexander Isak missed both matches with a groin issue while Fabian Schar and Joelinton were withdrawn against Fulham and Anthony Gordon and Emil Krafth were forced off at Chelsea on Tuesday night.
Eddie Howe claimed in his pre-match press conference on Friday morning that all five players would be subject to late fitness class ahead of the trip to Luton Town on Saturday (3pm kick-off). The quintet add to Newcastle's lengthy list of players currently ruled out.
Newcastle head into the match with 13 players ruled out or doubtful. It will be the club's first Premier League visit to Luton Town and Eddie Howe's first league match as manager against The Hatters since his fourth match in charge at AFC Bournemouth in League Two 15 years ago.
Newcastle head into the game looking to bounce back from a late Carabao Cup exit on penalties against Chelsea after conceding a 92nd minute equaliser at Stamford Bridge. Last time out in the Premier League they beat Fulham 3-0 at St James' Park but their form on the road has left a lot to be desired.
The Magpies have won just once away from home in the league this season, an 8-0 win against Sheffield United. They will be hoping to inflict more misery on another newly-promoted side on Saturday afternoon.
Here is Newcastle United's injury list and estimated return dates...
1. Matt Targett (achilles)
Targett has been missing since picking up a hamstring injury against Man Utd back in November. He has featured on the bench in their last couple of outings before dropping out v West Ham and Everton in what is understood to be a minor setback in his recovery. Expected return: Tottenham Hotspur (H) - 13/04 | Getty Images
2. Kieran Trippier (calf)
Trippier was forced off during the 3-0 win over Wolves with a calf injury. He has since been ruled out for over a month. Set for another couple of weeks out at least. Expected return: Crystal Palace (A) - 24/04 | Getty Images
3. Nick Pope (shoulder)
Nick Pope dislocated his shoulder against Manchester United in December and required surgery. Eddie Howe has said the goalkeeper is still a number of weeks away and isn't expected back until 'late April'. Expected return: Sheffield United (H) - 27/04 | Getty Images
4. Tino Livramento (ankle)
Livramento picked up a twisted ankle injury at Chelsea which ruled him out for the Manchester City trip. He returned against West Ham United before suffering another ankle injury which will keep him out for another couple of weeks. Expected return: Burnley (A) - 04/05 | Getty Images