Newcastle United's injury list has gained five more players over the past week following matches against Fulham and Chelsea.
Alexander Isak missed both matches with a groin issue while Fabian Schar and Joelinton were withdrawn against Fulham and Anthony Gordon and Emil Krafth were forced off at Chelsea on Tuesday night.
Eddie Howe claimed in his pre-match press conference on Friday morning that all five players would be subject to late fitness class ahead of the trip to Luton Town on Saturday (3pm kick-off). The quintet add to Newcastle's lengthy list of players currently ruled out.
Newcastle head into the match with 13 players ruled out or doubtful. It will be the club's first Premier League visit to Luton Town and Eddie Howe's first league match as manager against The Hatters since his fourth match in charge at AFC Bournemouth in League Two 15 years ago.
Newcastle head into the game looking to bounce back from a late Carabao Cup exit on penalties against Chelsea after conceding a 92nd minute equaliser at Stamford Bridge. Last time out in the Premier League they beat Fulham 3-0 at St James' Park but their form on the road has left a lot to be desired.
The Magpies have won just once away from home in the league this season, an 8-0 win against Sheffield United. They will be hoping to inflict more misery on another newly-promoted side on Saturday afternoon.
Here is Newcastle United's injury list and estimated return dates...
1. Jacob Murphy (calf)
Felt a tight calf in the warm-up at Nottingham Forest that rendered him 'unusable' for the match. Expected return: AFC Bournemouth (H) - 17/02
2. Callum Wilson (chest)
Wilson managed to complete 90 minutes at Nottingham Forest but ended the match with his arm in a makeshift sling. Eddie Howe said after the game that he hopes the injury is not serious but it was too soon to tell. It has since been revealed the striker suffered a pectoral injury in his chest. Expected return: TBC
3. Alexander Isak (groin)
Newcastle's top scorer was forced off during Tuesday's 3-1 win at Aston Villa with a groin issue. While it's not thought to be serious, Eddie Howe said he could be out for the next couple of games Expected return: Arsenal (A) - 24/02
4. Matt Targett (hamstring)
Matt Targett has been on the sidelines after picking up a hamstring injury in the opening minutes of Newcastle’s 3-0 Carabao Cup win against Manchester United. The left-back had surgery on his hamstring in November and given a three month recovery time. Howe has since confirmed Targett is back on the grass but not running just yet. Expected return: Arsenal (A) - 24/02