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After two decades, Newcastle United are back in the Champions League and they face seven-time European champions AC Milan in their opening game.
The Magpies head to the San Siro having registered their second Premier League win of the season at the weekend having overcome a resilient Brentford side 1-0.
Howe rang the changes for that game and will definitely be without Joelinton, Joe Willock and Emil Krafth for the trip to the San Siro - but who will get the nod in Italy?
Here, we take a look at the Newcastle United side Howe could name to face AC Milan at the San Siro.
9. RW: Miguel Almiron
Although Almiron had to settle for a place on the bench against Brentford, he is expected to return to the first-team on Tuesday night. | Getty Images
10. ST: Alexander Isak
Possibly the biggest call facing Howe is who he will pick to start up front. Wilson was the match winner at the weekend, however, Isak has had that extra time to recover and he may be asked to lead the line on Tuesday evening. | Getty Images
11. LW: Anthony Gordon
Gordon has become a key player under Howe this season and will be tasting his first experience of European football on Tuesday evening. | Getty Images