The Magpies’ first Premier League game came on August 14, 1993 when they faced Tottenham Hotspur.
In their debut season, they remarkably finished in third position and ever since then, the Newcastle journey has stopped off at title-challengers, European football, mid-table mediocrity, flirting with relegation, eventual relegation a brief European journey before being back to flirting with relegation again.
It started with Kevin Keegan and in their 1000th game, they will be led out by Steve Bruce.
For 27 seasons, United have been on a Premier League roller-coaster, but what do the stats tell us about their journey?
Have they racked up more wins than defeats? How many goals have they scored?
Here, we have summarised everything you need to know about Newcastle’s last 999 games in the Premier League:
5. Goals For: 1337
Despite struggling in-front of goal over the last few seasons, Newcastle United’s ‘entertainers’ probably helped to boost this number. Of course, the Premier League’s all-time top-scorer Alan Shearer has scored more of those goals for Newcastle than any other player - netting 148 times. (Mandatory Credit: Stu Forster /Allsport) Photo: Stu Forster
6. Goals Against: 1363
Steve Bruce’s side have conceded eight goals already this season and it is already looking like by the time May rolls around, their all-time Premier League goal difference will increase past the current total of -26. (Photo by Shaun Botterill/Getty Images) Photo: Shaun Botterill
7. Points per game: 1.36
On average, Newcastle take 1.36 points per Premier League game. Over a season, this would get them just less than 52 points per season - a tally that would steer them clear of any relegation danger. (Photo by MATTHEW CHILDS/POOL/AFP via Getty Images) Photo: MATTHEW CHILDS
8. Seasons spent in PL: 27
Newcastle are just one of eight teams to play in more than 25 seasons of the Premier League. Arsenal, Manchester United, Liverpool, Chelsea, Tottenham, Everton and Aston Villa are the other sides. (Photo by Chris Cole/Allsport/Getty Images) Photo: Getty Images