Eddie Howe has named four changes to the side that beat Everton 4-1 at Goodison Park on Thursday with Callum Wilson, Sean Longstaff, Matt Targett and Miguel Almiron all dropping out in place of Alexander Isak, Anthony Gordon, Dan Burn and Jacob Murphy.
Wilson, Targett and Almiron have all dropped to the bench while Longstaff is out after picking up a foot injury at Everton. Joelinton was also listed as a hamstring injury concern following the win but he has been deemed fit enought to start after playing the full 90 minutes on Thursday.
It means Kieran Trippier, who leads the side out, is the only Newcastle player to have featured in all 41 matches so far this season.
Newcastle go into the match looking to continue their fine run of form which has seen them pick up 21 points out of the last 24 available. A win against a struggling Southampton side would further boost The Magpies’ Champions League hopes.
United currently sit third in the Premier League table, eight points inside the Champions League places with a game in hand and just six games to play.
Meanwhile Southampton are struggling at the bottom of the Premier League table with just 24 points, six points from safety and 38 behind Newcastle in the table.
Here is the Newcastle United line-up to face Southampton at St James’ Park in full...
5. LB: Dan Burn
Could come back into the side after a rare start on the bench at Everton. Has been suffering with tonsilitis. Photo: Stu Forster
6. CM: Bruno Guimaraes
Has scored two in two Premier League matches against Southampton but was sent off against The Saints in the Carabao Cup at St James’ Park. Photo: Stu Forster
7. CM: Joe Willock
Grabbed another assist on Thursday night and will be looking to continue his fine run of form. | Getty Images
8. CM: Joelinton
In a rich vein of form in front of goal with four in his last five matches (five in five if you include the David Raya own goal at Brentford). | Getty Images