But who replaces the talismanic frontman this evening for the visit of the newly-crowned top flight champions?
Our Newcastle United writer Liam Kennedy takes a look at the side he would pick – and it not only includes a change up top to make up for the absence of Wilson, but also sees a little reshuffle further back.
9. Miguel Almiron
Out of sorts and out of position but it is still hard to make a case for the dropping the player. Photo: Michael Regan
10. Allan Saint-Maximin
Quiet by his standards against the Foxes, ASM will be looking to make an impression against City. And he might find he gets a little more space to do so. Photo: ALEX PANTLING
11. Joelinton
United don't have an out-and-out replacement for Callum Wilson and it is a straight shout between Dwight Gayle and the Brazilian for me. Gayle has done nothing to suggest he deserves a recall, so Joelinton it is. Photo: Clive Brunskill