After taking seven points from a possible nine during their previous three games, there is a quiet sense of optimism that the Magpies could come away with something from Anfield – a ground they haven’t won on since April 1994.
That said, Jurgen Klopp’s side, who have lost at home to Fulham, Brighton and Burnley this season, head into the fixture with everything to play for in their race to claim a Champions League spot.
Klopp confirmed in his pre-match press conference that midfielder Curtis Jones is back in contention, however Nathaniel Phillips, Jordan Henderson, Joel Matip, Joe Gomez, Virgil van Dijk and Divock Origi remain out.
Nevertheless, the German has plenty of options to select from as Newcastle eye a shock result to significantly boost their Premier League survival hopes.
Take a look through our gallery as we predict the Liverpool starting XI to face Bruce’s side:
9. Mohamed Salah (in for Roberto Firmino)
Mo Salah is likely to return to Klopp’s starting XI after being dropped to the bench at Leeds United on Monday night. Photo: Laurence Griffiths
10. Diogo Jota
A revelation since moving to Anfield from Wolves last summer. Jota has scored 12 goals in all competitions. Photo: PETER POWELL
11. Sadio Mane
Mane ended his drought of nine games without a goal by scoring the opener against Leeds last time out. Photo: Laurence Griffiths