The Red Devils played in the Europa League on Thursday and emerged victorious with a resounding 4-0 win against Real Sociedad in Italy.
In order to keep his squad as fresh as possible, Solskjaer has confirmed he will make changes for the visit of Steve Bruce’s men to Old Trafford.
The Norwegian boss said: “Of course, it’s such a tight schedule and, as you saw today, we rotated quite a bit and made some changes after about an hour.
"It’s good for minutes and for form and for everyone. We’ve got to make changes, keep freshening up and then Sunday already, here we go again.”
What changes could Solsjkaer make to his Manchester United line-up?
It’s a big game for both teams as Newcastle strive to pull away from relegation danger. The Red Devils, on the other hand, still have a slim chance at winning the title.
Take a look through our gallery as we predict Solskjaer’s starting XI against the Magpies:
1. David de Gea
The Manchester United number one was rested on Thursday after Dean Henderson was given the nod instead. Photo: Alex Pantling
2. Aaron Wan-Bissaka
The right-back has missed just five of the Red Devils’ 38 matches in all competitions this season. Photo: Pool
3. Victor Lindelof
Lindelof watched Manchester United’s win on Thursday from the bench, which suggests he’ll be used to freshen things up on Sunday. Photo: NAOMI BAKER
4. Harry Maguire
Manchester United’s captain. The 27-year-old has played every minute in the Premier League so far this season. Photo: Laurence Griffiths