Steve Bruce’s side beat the Hammers at the London Stadium on the opening weekend of last season courtesy of goals from Callum Wilson and Jeff Hendrick.
However, if supporters cast their minds back before then, they’ll know their team don’t tend to perform well during the first game of the season.
A new study by Bookmakers.TV has looked at the results of all 20 Premier League clubs across a decade of opening day fixtures – placing teams in order of best to worst.
Here’s how Newcastle compared to their English top-flight rivals:
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1. Manchester City
Played: 10. Won: 10. Drawn: 0. Lost: 0. Goals For: 29. Goals Against: 3. Goal Difference: 26. Points: 30. Points Per Game: 3. Photo: Michael Regan
2. Manchester United
Played: 10. Won: 8. Drawn: 0. Lost: 2. Goals For: 22. Goals Against: 7. Goal Difference: 15. Points: 24. Points Per Game: 2.4. Photo: Laurence Griffiths
3. Liverpool
Played: 10. Won: 7. Drawn: 2. Lost: 1. Goals For: 24. Goals Against: 15. Goal Difference: 9. Points: 23. Points Per Game: 2.3. Photo: Pool
4. Chelsea
Played: 10. Won: 6. Drawn: 2. Lost: 2. Goals For: 19. Goals Against: 12. Goal Difference: 7. Points: 20. Points Per Game: 2. Photo: Michael Steele