So far Newcastle have already had two of their internationals hit by injury with Alexander Isak withdrawing from the Sweden squad and Bruno Guimaraes picking up an injury in training with Brazil.
The break does allow the likes of Callum Wilson and Allan Saint-Maximin, who are both nearing returns following their respective hamstring injures, to get closer to contention.
Next up for United in the Premier League is a trip to face Fulham on October 1 (3pm kick-off).
But which players will be available to make the trip to Craven Cottage?
Here is Newcastle United’s current injury list as it stands as well as potential return dates...
5. Allan Saint-Maximin - hamstring
The French winger suffered a slight hamstring issue following his stunning late equaliser at Wolverhampton Wanderers in August. He was close to a return but had a slight set-back that could keep him out of the upcoming match against Fulham. Potential return date: 08/10 (Brentford - H) Photo: Eddie Keogh
6. Jonjo Shelvey - hamstring
The midfielder suffered a serious hamstring injury during the 3-2 defeat at Benfica during pre-season, facing a number of months on the sidelines. Potential return date: 05/11 (Southampton - A) Photo: Gualter Fatia
7. Karl Darlow - ankle
Darlow suffered a twisted ankle in training, forcing Newcastle to make a move for free agent goalkeeper Loris Karius as a short-term replacement. Potential return date: 26/12 (Leicester City - A) Photo: Gualter Fatia
8. Emil Krafth - ACL
The Swedish right-back is facing a lengthy spell on the sidelines and could potentially be out for the remainder of the season after rupturing his anterior cruciate ligament against Tranmere. Potential return date: March 2023 – pre-season) | Getty Images