An early brace from Sean Longstaff put Newcastle into a commanding lead early on before a Che Adams strike reduced the deficit for Southampton to 2-1 on the night and 3-1 on aggregate going in at half-time.
It was the first goal Nick Pope had conceded in 11 matches to set up a slightly nervous second half at St James’s Park for The Magpies.
A late sending off for Bruno Guimaraes following a VAR check made things even more nervous for the hosts in the closing stages but they kept their two-goal advantage intact.
Here are the Newcastle United player ratings from the match...
9. Miguel Almiron - 6
Showed good movement and decision making to cut the ball back for Longstaff’s second. Was reasonably quiet otherwise. | AFP via Getty Images
10. Joelinton - 7
Released Joe Willock in the build-up to the second goal. Showed a few classy turns and touches when on the ball though still prone to the odd unsuccessful touch. | Getty Images
11. Callum Wilson - 6
Had no real chances but held the ball up well and battled before being withdrawn as his goalless run continues. | Getty Images
12. Allan Saint-Maximin - 6
On for Willock 61: Helped stretch the game with his pace and trickery in the closing stages. Photo: Michael Regan