Steve Bruce’s twice took the lead through Callum Wilson and then Allan Saint-Maximin in the 90th minute, which looked to have won the game.
However, a penalty conceded by captain Jamaal Lascelles allowed Ward-Prowse to equalise from the spot to deny the Magpies their first win of the campaign.
How did each player fare during the 2-2 draw? Our writer Miles Starforth was at St James’s Park and dished out his player ratings:
A message from the Football Clubs Editor
Our aim is to provide you with the best, most up-to-date and most informative Newcastle United coverage 365 days a year.
This depth of coverage costs, so to help us maintain the high-quality reporting that you are used to, please consider taking out a subscription; sign up here.
Your support is much appreciated. Richard Mennear, Football Clubs Editor
9. Miguel Almiron - 6
Full of running, tracked back time and again, but wasn’t a threat with the ball Photo: Ian MacNicol
10. Allan Saint-Maximin - 8
Much better after the break, played with more intent, and put Southampton on the back foot. His late goal should have claimed all three points Photo: George Wood
11. Callum Wilson - 7
Put Newcastle ahead to make it two goals from three Premier League games, left the field with a thigh injury which had seemingly hampered him Photo: George Wood
12. Joelinton (for Wilson, 69) - 6
Involved in the build-up to Saint-Maximin's goal. Photo: George Wood