Both sides have started the season slowly, and both find themselves towards the foot of the table and still looking for a win after four matches.
Speaking ahead of the game, Magpies boss Steve Bruce, who continues to face scrutiny from supporters over the side's results and style of play, said: “I've said now since I walked through the door two years ago, I'm not going to be everybody's cup of tea, but I will, with my experience, hope that I can keep the club just ticking along, and make sure we maintain our Premier League status.
“We should be better than that, (but) that's where we are at the moment, and we have been for a while, and that's everybody's frustration.
“I want Newcastle to be at the top of the league, so that frustration is there. But I don't think 'oh, the noise is too bad, walk away, Steve'. That's not in my nature when it gets tough.”
Meanwhile, Leeds boss Marcelo Bielsa expressed sympathy for Bruce amid the pressure on his job, and revealed: “I always feel saddened when this happens to a manager, when his home fans go against him.
“It is one of the worst feelings that a manager can have.”
Take a look at the latest news round-up from the Premier League, as the build-up to the weekend's action continues:
5. Guardiola frustrated over low attendance
Pep Guardiola has urged more Manchester City fans to attend their game against Southampton, after just over 38,000 fans attended their midweek Champions League game clash against RB Leipzig, despite their stadium having a 55,000 capacity. (BBC Sport) Photo: Richard Heathcote
6. Lewandowski open to Reds switch
Bayern Munich superstar Robert Lewandowski is said to be "open" to a move to Liverpool, as he begins to consider the possibility of a new challenge. The Polish striker has played the last decade of his career in the Bundesliga, winning nine league titles. (Fichajes) Photo: David Ramos
7. Whites want Phillips agreement this year
Leeds United are said to have opened talks with Kalvin Phillips over a new, big-money deal, and have reportedly set the goal of reaching an agreement before the end of the year. A host of the Whites' divisional rivals were linked with Phillips over the summer. (Football Insider) Photo: OLI SCARFF
8. Reds ready raid for teenage ace
Liverpool have been tipped to launch a move for RB Salzburg teenager Karim Adeyemi. The talented striker has scored six goals in seven matches for his club so far this season, and made his debut for Germany's senior side earlier n the month. (Mundo Deportivo) Photo: Alexander Hassenstein