The Magpies have a largely solid record against the Blues at home in recent years, and will be hopeful of securing another positive results against the Blues in front of a packed stadium once again.
Meanwhile, the club continue to search for a successor to Steve Bruce, as they look to find the right candidate to take them into the new era following the big-money takeover.
Discussing the options open to the Magpies, talkSPORT pundit Simon Jordan said: “This football club is going to be an opportunity for someone, it’s when you take that opportunity.
“And I just think the sensible thing for Newcastle would be to some way or another, find an interim appointment until they work out who they are, what they are and get a clean slate.
“Now, you have got to try and find a way to stay in the division and that to me feels like a job for someone who knows how to do that and then build on that platform with somebody who comes in that’s an elite manage and give him the embarrassment of riches he would be entitled to.”
The likes of ex-Roma boss Paulo Fonseca, former Borussia Dortmund manager Lucien Favre, and 47-year-old Leonardo Jardim are believed to be the current front-runners for the position.
Here is our rundown of the latest news and updates from the Premier League, as the build-up to this weekend's eagerly-anticipated action continues:
5. Phillips 'favours' Liverpool over Man Utd
Leeds United are believed to be working hard to tie star man Kalvin Phillips down to a new deal, amid interest from Liverpool and Man Utd. While the England ace is "reluctant" to leave the Whites, he is said to "favour" a move to the Reds over Leeds' fierce rivals. (Daily Star) Photo: George Wood
6. West Ham takeover moves closer
Czech billionaire Daniel Kretinsky is understood to have bought a stake close to 30% in West Ham United, opening up the possibility of a full takeover in the future. The initial stake purchase is said to value the club between £600m and £700m. (Sky Sports) Photo: THOMAS SAMSON
7. Spurs urged to sign Maddison
Spurs have been urged to consider a move for Leicester City midfielder James Maddison, as they look to add a spark of creativity to their struggling side. The 24-year-old has been with the Foxes since 2018, and has one senior cap for England. (Football Insider) Photo: Catherine Ivill
8. Alli tipped to leave Spurs
Football pundit Alex McLeish has tipped Spurs to sell midfielder Dele Alli in January, and invest heavily in new signings to save their season. Nuno Espirito Santo's side have lost four of their nine Premier League games in the campaign thus far. (Football Insider) Photo: Martin Rose