The Red Devils, who now has superstar Cristiano Ronaldo back among their ranks, will be pushing for the title this season, and the Magpies will need to be at their best to secure a positive result against the hosts.
Meanwhile, Newcastle talisman Allan Saint-Maximin has opened up on why he opted to remain at the club despite having the potential to leave the club for a hefty fee in the last transfer window. He revealed: “I’ve got a really good connection (with the fans). That’s why I decided to stay at Newcastle.
“For the love and the support they give me, it’s so important for me and they deserve more. Last season, it was a long time without supporters so every goal I scored I could not celebrate with them.”
He added: “It’s difficult when you feel everything is against you. We have conceded three penalties (so far this season). It’s hard but sometimes this happens and it’s better to happen at the start of the season.
“Everyone feels good because we know how hard we work in training. I feel really tired because we are working a lot. We just have to keep going, even if things go against us.
“We have to keep our head up because if the head goes down, it’s more difficult for everyone.”
Take a look at the latest news round-up from the Premier League, as the build-up to the weekend's action continues:
5. Burnley target makes surprise switch elsewhere
Burnley linked winger Thomas Robert has sealed a surprise move from Airdrie to Belgium, joining second-tier side Royal Excel Mouscron. The 21-year-old Frenchman is the son of Newcastle United icon Laurent Robert. (Daily Record) Photo: Nigel Roddis
6. Gunners knock back Elneny bid
Arsenal are believed to have rejected a bid for their £7m midfielder Mohamed Elneny from Galatasaray. The Egypt international could yet leave the club this month, with transfer windows in Turkey and the Czech Republic still open. (Football.London) Photo: Stu Forster
7. Pundit makes bold Phillips claim
Football pundit Gabby Agbonlahor has claimed it is "only a matter of time" until Leeds United sell star midfielder Kalvin Phillips. He's suggested the England international will leave Elland Road to pursue Champions League football. (Football Insider) Photo: George Wood
8. Juve keen on Cavani
Juventus have been linked with a January move for Manchester United striker Edinson Cavani. The veteran forward, who gave up his number seven shirt to new signing Cristiano Ronaldo, is also said to be of interest to Boca Juniors. (Sport Witness) Photo: Michael Regan