The Magpies are five games unbeaten in the Premier League and are four points clear of the relegation zone. That gap will be temporarily extended to seven points if Eddie Howe's side manage to win at The London Stadium in the early kick-off match.
But the Newcastle head coach still has a few fitness concerns with right-back Kieran Trippier facing an extended spell on the sidelines after fracturing his fifth metatarsal in Sunday’s 1-0 win over Aston Villa, in which he scored the winning goal.
Javier Manquillo is also likely to miss the trip with an ankle ligament injury.
Matt Targett is back in contention and Jamaal Lascelles is also expected to return after missing last weekend due to illness. Meanwhile, Bruno Guimaraes is still waiting to make his full Newcastle debut.
A message from the Football Clubs Editor
Our aim is to provide you with the best, most up-to-date and most informative Newcastle United coverage 365 days a year.
This depth of coverage costs, so to help us maintain the high-quality reporting that you are used to, please consider taking out a subscription; sign up here.
Your support is much appreciated. Richard Mennear, Football Clubs Editor
Javier Manquillo is also likely to miss the trip with an ankle ligament injury.
5. Kieran Trippier - foot
After scoring two free-kicks in as many games, Newcastle are now set for an extended period without the influential right-back. The 31-year-old fractured his fifth metatarsal after being stamped on in Sunday's win against Aston Villa and wast spotted with crutches and a protective boot following an x-ray. We may not see him in competitive action again until April providing his rehab goes smoothly. Photo: Stu Forster
6. Javier Manquillo - ankle
Newcastle have somewhat of a dilemma at right-back with Manquillo also being forced off against Aston Villa at the weekend with an ankle injury. Eddie Howe said after the game that the Spaniard had suffered some suspected ankle ligament damage however it isn't as bad as first feared. He is set to miss the trip to West Ham but could be back in contention by the end of the month. Photo: Stu Forster
7. Jamaal Lascelles - illness
Missed the Aston Villa game due to a non-Covid related illness. He has since returned to full training and should be fine to face West Ham this weekend if called upon. Photo: Alex Livesey
8. Isaac Hayden - knee
The midfielder picked up a serious knee injury in December and has been ruled out for the remainder of the season having been left out of Newcastle's 25-man squad as a result. Photo: Stu Forster