Kieran Trippier fractured the fifth metatarsal bone in his left foot and faces a long injury lay-off.
This news will come as a major blow to Eddie Howe who has seen his side collect ten points from their last four Premier League games, a run that has helped catapult United out of the relegation zone who currently find themselves in 17th and four points above Norwich City
New signing Matt Targett made his full debut against Everton whilst Dan Burn played a pivotal role in helping to secure victory against Villa on Sunday. Bruno Guimaraes has made fleeting appearances as a substitute in games against the Toffees and Villa.
Here, we take a look at the very latest injury news affecting Newcastle United ahead of the clash with West Ham:
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5. Matt Ritchie - knee
There isn't too much certainly on Ritchie's injury status as he hasn't been seen in training or match action since Eddie Howe said the 32-year-old had an issue with his knee ahead of the Leeds match. He was spotted at Fratton Park on deadline day for Portsmouth's 2-1 defeat to Charlton Athletic in League One. He remains a doubt for Sunday's game as it stands. Photo: Stu Forster
6. Jamaal Lascelles
Newcastle's captain missed the victory over Aston Villa on Sunday through illness. Their current defensive injury worries mean that it's hoped he can make his return to full fitness ahead of Saturday's game in the capital. Photo: Alex Livesey
7. Ciaran Clark
Left out of Newcastle's 25-man squad and unavailable for selection. Photo: Stu Forster
8. Federico Fernandez - thigh
The centre-back suffered an injury just before Christmas and is yet to feature since. He travelled to Saudi Arabia and took part in some light training but is still expected to be out for some time yet. Photo: Stu Forster