But what about the other contenders? Who do the bookies think will go and who do they think will be safe?
Here we take a look at the runners and riders using SkyBet’s Premier League relegation odds.
5. Burnley - 9/4
Despite winning one of their opening two the bookies still think Sean Dyche's men are a good shout to drop to the Championship. Photo: Julian Finney
6. Crystal Palace - 5/2
After a summer of uncertainty, Crystal Palace have picked up one point from their opening two games - including a defeat to Sheffield United. Roy Hodgson might have held on to Wilfried Zaha, but he's still got plenty of headaches. Photo: Jan Kruger
7. Watford - 3/1
Watford are bottom of the pile after two games having lost both and failed to score. Photo: Warren Little
8. Southampton - 10/3
Last season the Saints had a flirt with the drop, and this time around it seems like it will be no different. No points, five conceded and just one goal scored. Photo: Warren Little