Newcastle United dealt double injury blow ahead of Premier League clash at Aston Villa
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The midfielder missed the majority of pre-season with the same problem, though head coach Steve Bruce revealed this was his opposite calf.
Shelvey started the 4-2 opening day Premier League defeat to West Ham United on Sunday at St James’s Park before being replaced by Ryan Fraser on 70 minutes.
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Hide AdBruce said: "We don’t think Jonjo will make it, unfortunately.


"He had a calf injury during pre-season and this is his other one (calf). He won’t make it.”
The 60-year-old confirmed Freddie Woodman will make his second top-flight appearance with Martin Dubravka and Karl Darlow sidelined still.
“The two goalkeepers are a long way off, Bruce continued. "That’s a concern for us. Freddie will play in goal again.”
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Hide AdBruce revealed Dubravka has suffered a setback in his recovery from a foot injury.
The Slovakian underwent surgery on a stress fracture in July after appearing at Euro 2020.
Bruce said: “It’s not great when you’ve got your two most experienced goalkeepers struggling.
"Martin, unfortunately, the injury he had has become infected which will set him back another few weeks.
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Hide Ad"Karl still hasn’t overcome the Covid situation he found himself in.
"It’s difficult for us at the moment. Those two are still a long way off.”
Bruce admits it is causing a headache ahead of submitting his 25-man Premier League squad at the end of August.
He said: "We’ve got a problem with the goalkeeping situation at the moment where we are toying with the idea of naming four in the squad, which is basically unheard of.
"It’s a big concern for us.”