The Newcastle United striker suffered what was described as a “devastating” hamstring injury in the win over Southampton earlier this month – and Bruce revealed last week that Wilson could be out until April.
Fabian Schar and Javier Manquillo also suffered knee and ankle injuries respectively in the Premier League game.
Asked for an update on Wilson, Schar and Manquillo, Bruce said: “I don’t think we could put a timescale on it.
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"Fab Schar’s had his operation. Callum is a muscle injury. We’ve just got to be patient and wait. They’re OK. The one who looks better is Manquillo. He twisted his ankle badly, but has responded very well to treatment. The other two, Fab’s had his operation. We know Callum. We’ve just got to be patient with him. We’ll give him as much time as he needs.”
Wilson, signed from Bournemouth last summer in a £20million deal, is United's leading scorer with 10 goals.
And the relegation-threatened club, which had to temporarily shut its training ground late last year due to a Covid-19 outbreak, has been badly hit by injuries and illness this season.
“There’s one problem after the other,” said head coach Bruce. “We did predict it all, all of us managers, with the amount of games in a short period of time.
"Unfortunately, with Callum, of course, he was centre-forward, and been crucial to us this year. We’re going to have to do without him for a few weeks. That’s the way it is.”