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A threadbare Newcastle United head to the capital after a disappointing defeat to Everton in midweek.
The Magpies were beaten 3-0 on Merseyside as Eddie Howe was yet again forced to name the same ten outfield players that had started their previous three matches as injury problems continue to persist.
However, there does seem to be a small chink of light at the end of the tunnel with a few of those injured players seemingly close to a return to the fold, although how quick they are able to do that is unknown.
Ange Postecoglou, meanwhile, also saw his side fall to defeat on Thursday night as he shares a similar headache as his opposite number.
Here, we take a look at the latest injury news from both camps ahead of the clash between Tottenham Hotspur and Newcastle United:
17. Matt Targett - out
Targett was substituted very early on against Manchester United in the Carabao Cup after suffering a hamstring injury. The left-back has undergone surgery on the injury and will thus miss the next few months of action. | Getty Images
18. Sven Botman - doubt
The Dutchman still has a little longer to go in his recovery from a knee injury. Botman hasn’t featured for the club since the win over Sheffield United and will miss the clash against Everton. There is hope he will be available for selection soon, however after a recent social media post hinted that Botman could be back in contention for selection soon. | Getty Images
19. Elliot Anderson - out
Anderson has suffered a back injury and could be sidelined for a further six weeks with the injury. With a very hectic schedule to come, not having Anderson’s services will be a huge blow for the Magpies. | AFP via Getty Images
20. Sandro Tonali - out
Tonali was handed a 10-month ban from football meaning he won’t be available for selection between now and the beginning of next season. | Getty Images