Eddie Howe’s side make the trip to the capital and face a Spurs side that they did the double over last season.
However, the Magpies travel to the capital on the back of a disappointing midweek defeat to Everton and with a host of key players still sidelined through injury.
Spurs, meanwhile, were also defeated in midweek and Ange Postecoglou faces a similar headache and the possibility of not having his club captain, Son Heung-min, available after he picked up a knock against the Hammers.
Here, we take a look at the starting XI line-ups Newcastle United and Tottenham Hotspur could name for the clash this evening:
1. Guglielmo Vicario
Vicario has impressed for Spurs this season after joining the club from Empoli in the summer.
2. Pedro Porro
The Spaniard has five assists this season having missed just two minutes of league action all season.
3. Cristian Romero
The Argentine returned to the starting team after suspension in midweek and netted Spurs’ only goal against the Hammers.
4. Ben Davies
Davies scored against Newcastle when Spurs defeated Eddie Howe’s side 5-1 a couple of seasons ago.