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Eddie Howe’s side make the trip to the capital and face a Spurs side that they did the double over last season.
However, the Magpies travel to the capital on the back of a disappointing midweek defeat to Everton and with a host of key players still sidelined through injury.
Spurs, meanwhile, were also defeated in midweek and Ange Postecoglou faces a similar headache and the possibility of not having his club captain, Son Heung-min, available after he picked up a knock against the Hammers.
Here, we take a look at the starting XI line-ups Newcastle United and Tottenham Hotspur could name for the clash this evening:
1. Guglielmo Vicario
Vicario has impressed for Spurs this season after joining the club from Empoli in the summer. | Getty Images
2. Pedro Porro
The Spaniard has five assists this season having missed just two minutes of league action all season. | Getty Images
3. Cristian Romero
The Argentine returned to the starting team after suspension in midweek and netted Spurs’ only goal against the Hammers. | Getty Images
4. Ben Davies
Davies scored against Newcastle when Spurs defeated Eddie Howe’s side 5-1 a couple of seasons ago. | Getty Images