Newcastle head coach Eddie Howe had several injury concerns heading into the game.
Allan Saint-Maximin and Alexander Isak were doubts ahead of the match and didn’t travel to Old Trafford.
But one player who did make the trip was Jonjo Shelvey. The midfielder was named in the Newcastle squad for the first time this season after picking up a hamstring injury in pre-season.
NUFC line-up: Pope; Trippier, Schar, Botman, Burn; Guimaraes, Longstaff, Joelinton; Murphy, Almiron, Wilson
Subs: Karius, Lascelles, Shelvey, Lewis, Targett, Wood, Fraser, Willock, Anderson
1. Allan Saint-Maximin - hamstring
The Newcastle winger has suffered a setback after returning from a hamstring injury off the bench against Brentford earlier this month. Photo: Ian MacNicol
2. Alexander Isak - thigh
Alexander Isak withdrew from international duty with Sweden due to a thigh injury. He remains sidelined following a significant setback. He is not expected to return until after the World Cup. Photo: George Wood
3. Matt Ritchie - calf
The winger suffered a calf injury in training during the international break. He is fighting to be back available before the World Cup break. Photo: Stu Forster
4. Karl Darlow - ankle
The goalkeeper is back in light training as he recovers from an ankle injury. Photo: Gualter Fatia