Allan Saint-Maximin and Callum Wilson drop out of the side for Joe Willock and Alexander Isak. Wilson scored twice for Newcastle at West Ham but drops back to the bench in favour of Isak, who has scored four goals in his last four appearances.
Saint-Maximin drops out of the squad entirely with a hamstring issue. Newcastle are looking to secure a fifth straight Premier League win and continue their charge for Champions League charge.
The Magpies currently sit 10 points ahead of Brentford in the Premier League table.
NUFC XI to face Brentford: Pope; Trippier, Schar, Botman, Burn; Guimaraes, Longstaff, Willock; Joelinton, Murphy, Isak
NUFC Substitutes: Dubravka, Dummett, Lascelles, Gordon, Wilson, Ritchie, Targett, Manquillo, Anderson
Here are Newcastle United’s absent players this afternoon...
5. Harrison Ashby - tactical
Yet to be involved in a matchday squad since his deadline day arrival. Was nursing a hamstring injury but returned to full training last month. Photo: PAUL ELLIS
6. Loris Karius - tactical
Remains out of the squad with Martin Dubravka on the bench as back-up goalkeeper. Photo: ADRIAN DENNIS
7. Mark Gillespie - tactical
Newcastle’s fourth choice goalkeeper doesn’t make the squad today. Photo: Pool
8. Emil Krafth - ACL
Picked up a serious knee injury in the second round of the Carabao Cup back in August. | Getty Images