Eddie Howe has made eight changes to the Newcastle side that beat Southampton 4-1 in the Premier League on Sunday. Nick Pope, Dan Burn and Sean Longstaff are the only three players to keep their place in the starting line-up from the weekend.
NUFC line-up: Pope; Manquillo, Lascelles, Burn, Targett; Shelvey, Longstaff, Joelinton; Anderson, Saint-Maximin, Wood
Subs: Karius, Trippier, Botman, Schar, Lewis, Murphy, Almiron, Willock, Guimaraes
Several first team players have not been included in the matchday squad, here’s why...

1. Alexander Isak - thigh
The striker has been out of action since withdrawing from international duty with Sweden due to a thigh injury. He has received injections and continues to progress with a view to returning to action after the World Cup break. | Getty Images

2. Loris Karius - tactical
Karl Darlow is the preferred goalkeeper option on the bench this afternoon. Photo: Ian MacNicol

3. Matt Ritchie - calf
The winger suffered a calf injury in training during the international break. It was hoped he could return before the World Cup break, but the game has come just too soon for him. Photo: Stu Forster

4. Jamal Lewis - tactical
Matt Targett and Javier Manquillo are the preferred full-back options on the bench after both started in the Carabao Cup on Wednesday evening. Photo: Ian MacNicol