Eddie Howe has made just one change from Wednesday night’s 1-0 win over Everton with Joe Willock coming into the starting line-up in place for Jacob Murphy.
Joelinton keeps his place in the side after an injury scare while Bruno Guimaraes also starts less than 48 hours after the birth of his first child.
But several Newcastle players remain sidelined for the match, and we’ll be looking at the reasons why.
NUFC line-up to face Tottenham Hotspur: Pope; Trippier, Schar, Botman, Burn; Guimaraes, Longstaff, Willock; Almiron, Joelinton, Wilson
NUFC subs: Karius, Lascelles, Shelvey, Lewis, Targett, Manquillo, Wood, Fraser, Murphy
5. Elliot Anderson - knock
The young midfielder was understood to be pushing for his first start of the season after coming off the bench against Everton. But he has been left out of Eddie Howe’s squad this afternoon. Photo: Stu Forster
6. Emil Krafth - ACL/not in squad
The right-back has been left out of Newcastle’s squad for the first half of the campaign after suffering a serious knee injury. | Getty Images
7. Paul Dummett - calf
Dummett is yet to feature for Newcastle in the Premier League this season and is currently recovering from a calf injury. | Getty Images
8. Mark Gillespie - not in squad
Despite being given a squad number (29), Mark Gillespie has not been included in Newcastle’s 25 man squad. Nick Pope, Loris Karius and Karl Darlow are the three goalkeepers in Eddie Howe’s squad. Photo: Gualter Fatia