Eddie Howe has made eight changes to the side that were beaten 2-1 at Sheffield Wednesday in the FA Cup on Saturday and reverted back to the same side that drew 0-0 with Arsenal last time out in the Premier League. Alexander Isak has returned from a thigh injury to make the bench while Allan Saint-Maximin is also back in the squad after suffering from illness.
Nick Pope, Fabian Schar and Callum Wilson are also back in the squad after being rested for the match at Hillsborough.
But there are still several players who are ineligible to feature and missing through injury.
The Magpies will be hoping to reach the semi-final of the League Cup for the first time since 1976 as they face three-time winners Leicester, a side they beat 3-0 in the league in Boxing Day.
NUFC XI: Pope; Trippier, Schar, Botman, Burn; Guimaraes, Longstaff, Willock; Almiron, Joelinton, Wilson
Subs: Darlow, Lascelles, Saint-Maximin, Ritchie, Isak, Manquillo, Wood, Murphy, Anderson
Here are Newcastle United’s missing players against Leicester City...
1. Bruno Guimaraes - suspended
Serving the final match of his three game red card suspension. | Getty Images
3. Ryan Fraser - tactical
Misses out on the matchday squad with Anthony Gordon, Jacob Murphy and Matt Ritchie the preferred wide options. | Getty Images
4. Harrison Ashby - tactical
Ashby has been training with the first team since his deadline day arrival at Newcastle but is yet to be included in a matchday squad. | AFP via Getty Images