Portsmouth defender Christian Burgess is feeling confident ahead of the play-offs.
We take a closer look at what to keep an eye on this weekend, with the league title, play-off spots and relegation places still to be decided.
The Black Cats will be keen to finish on a high following a shock defeat at Fleetwood on Tuesday. Southend have even more to play for and are only outside the relegation zone on goal difference.
Sunderland boss Jack Ross confirmed winger Aiden McGeady will miss the clash with a foot injury. Forward Charlie Wyke could return to the side after sitting out the Fleetwood defeat.
Sign up to our daily newsletter
The i newsletter cut through the noise
A win would ensure Southend, managed by Kevin Bond, would beat the drop. However, just three points separate 19th-place AFC Wimbledon and 23rd-place Scunthorpe.
Both Plymouth and Scunthorpe are in the drop zone ahead of the final day. A win for either side could see them survive, while the loser will be relegated from the third tier.
Portsmouth were resigned to the play-offs after losing to Peterborough on Tuesday, but defender Christian Burgess is feeling confident. "Everybody in the squad has big-game experience and that can stand us in good stead," he said.
Lyle Taylor and defender Patrick Bauer missed Charlton's victory over Gillingham last weekend but could return to face Rochdale. "I feel we need to give them time this weekend because of sharpness," said manager Lee Bowyer.
After securing automatic promotion with The Hatters, Luton caretaker boss Mick Harford will be replaced by Graeme Jones next season. Harford will hope to go out on a high against Oxford this weekend.
Barnsley are level on points with Luton and could still leapfrog The Hatters to lift the League One title. The Tykes face a trip to Bristol Rovers on the final day.
Following a win over Portsmouth on Tuesday, Peterborough could sneak into the final play-off spot this weekend. Posh need to win at home to Burton and hope Doncaster slip up against Coventry.
Just a point separates neighbours Blackpool and Fleetwood ahead of the final day. The Tangerines, who sit tenth, host Gillingham, while Fleetwood will travel to Wycombe.