Rafa Benitez's side take on the League Two leaders in a third-round tie at St James's Park.
United manager Benitez has named a strong starting XI for the game, which is expected to attract a crowd of more than 43,000.
Most Popular
-
1
Angry patient trashed doors at South Tyneside District Hospital after falling asleep and missing treatment
-
2
The 16 places where most crime was reported across South Tyneside in June
-
3
Man grew his own cannabis supply to help cope with back pain
-
4
Man broke into South Shields home of Good Samaritan who tried to help him
-
5
Woman’s death in South Shields' property treated as ‘unexplained’ while police inquiries ‘ongoing’
Goalkeeper Woodman replaced Karl Darlow between the posts.
The 20-year-old – who has had loan spells at Kilmarnock and Crawley Town –helped England's Under-20s win the World Cup last summer.
Jamaal Lascelles, Jonjo Shelvey, Dwight Gayle, Matt Ritchie and Mikel Merino have also been handed starts.
Meanwhile, Olly Lee, son of former Newcastle midfielder Rob, starts for Luton, while Elliot, his brother, is on his bench.
NEWCASTLE UNITED: Woodman; Manquillo, Lascelles, Clark, Dummett; Ritchie, Shelvey, Merino, Murphy; Perez, Gayle. Subs: Darlow, Diame, Hayden, Aarons, Joselu, Saivet, Haidara.
LUTON TOWN: Stech, Potts, Rea, Mullins, Justin, Ruddock, O Lee, Berry, Shinnie, Collins, Hytlon. Subs: Stacey, Cook, Cornick, Gambin, Shea, E Lee, Famewo