Newcastle United travel to the Vitality Stadium aiming to banish any demons from their narrow defeat to Borussia Dortmund in midweek - one that left their hopes of qualifying for the Champions League knockout stages hanging by a thread.
The Magpies were dealt another injury blow out in Germany with Callum Wilson being forced off at half-time after suffering a tightness in his hamstring.
Concern over Wilson adds yet another headache for Howe this weekend as he has to deal with a plethora of injuries plus a suspension for Bruno Guimaraes.
The hosts, meanwhile, also have a few problems to deal with ahead of this weekend’s game.
Here, we take a look at the latest injury and team news from both camps ahead of Bournemouth v Newcastle United:
1. Neto - out
Neto injured his ankle last month and Iraola doesn’t believe that he will have the Brazilian back in action until after the international break.
2. Alex Scott - doubt
Scott was heavily-linked with a move to Newcastle United during the summer but has been ruled as a doubt to feature against them this weekend.
3. Emiliano Marcondes - out
Marcondes had surgery on a foot injury during pre-season and he is yet to feature for the Cherries this season.
4. Darren Randolph - doubt
Randolph has missed Bournemouth’s last few outings through illness but was pictured in training last week ahead of their clash with Manchester City.