After two decades, Newcastle United are back in the Champions League and they face seven-time European champions AC Milan in their opening game.
The Magpies head to the San Siro having registered their second Premier League win of the season at the weekend having overcome a resilient Brentford side 1-0.
Howe rang the changes for that game and will definitely be without Joelinton, Joe Willock and Emil Krafth for the trip to the San Siro - but who will get the nod in Italy?
Here, we take a look at the Newcastle United side Howe could name to face AC Milan at the San Siro.
1. GK: Nick Pope
Pope secured his first clean sheet of the season at the weekend - can he make it two in two at the San Siro? | Getty Images
2. RB: Kieran Trippier
Trippier is one of the few members of the squad that heads to Milan with experience of playing in the Champions League. The former Spurs man will be relied on to lead the team into the unknown on Tuesday evening. | Getty Images
3. CB: Fabian Schar
Schar has issued a pre-match rallying call to his teammates, reiterating that the team aren’t there simply to make up the numbers. Schar has been one of Howe’s key players since arriving as manager and will deservedly have a role to play in their Champions League campaign. | Getty Images
4. CB: Sven Botman
AC Milan were very interested in signing Botman before his move to Newcastle United and the Dutchman will want to showcase his talents on the biggest stage once again. | Getty Images